Organic Chemistry · free preview

24.6 Synthesis of Amines

We’ve already seen in Section 20.7 and Section 21.7 how amines can be prepared by reduction of nitriles and amides with LiAlH_{\text{4}}. The two-step sequence of S_{\text{N}}2 displacement with CN^{\

1. Reduction of Nitriles, Amides, and Nitro Compounds

Reduction of Nitriles, Amides, and Nitro Compounds

2. Problem 24-8 (a) CH_{\text{3}}CH_{\text{2}}CH_{\text{2}}NH_{

Problem 24-8 (a) CH_{\text{3}}CH_{\text{2}}CH_{\text{2}}NH_{

3. SN2 Reactions of Alkyl Halides

SN2 Reactions of Alkyl Halides

4. A better method for preparing primary amines is to use azide

A better method for preparing primary amines is to use azide

5. Problem 24-9 Write the mechanism of the last step in Gabriel

Problem 24-9 Write the mechanism of the last step in Gabriel

6. Reductive Amination of Aldehydes and Ketones

Reductive Amination of Aldehydes and Ketones

7. Ammonia, primary amines, and secondary amines can all be use

Ammonia, primary amines, and secondary amines can all be use

8. Part 8

Part 8

9. Worked Example 24.1: Using a Reductive Amination Reaction

Worked Example 24.1: Using a Reductive Amination Reaction

10. Problem 24-11 (a) (b) (c) Problem 24-12 How could you prepar

Problem 24-11 (a) (b) (c) Problem 24-12 How could you prepar

11. Hofmann and Curtius Rearrangements

Hofmann and Curtius Rearrangements

12. Despite its mechanistic complexity, the Hofmann rearrangemen

Despite its mechanistic complexity, the Hofmann rearrangemen

13. Also like the Hofmann rearrangement, the Curtius rearrangeme

Also like the Hofmann rearrangement, the Curtius rearrangeme

14. Part 14

Part 14

15. Worked Example 24.2: Using the Hofmann and Curtius Rearrangements

Worked Example 24.2: Using the Hofmann and Curtius Rearrangements

16. Problem 24-13 (a) (b)

Problem 24-13 (a) (b)

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